Many women have heard of the complication of “pregnancy poisoning”. Although the term is outdated, it means- as we know today- a complex of several clinical pictures, of which we can make a prediction very early for preeclampsia, namely towards the end of the first trimester.
Ideally, we perform this calculation of the individual risk as part of the ETS, since we need a hormone (PAPP-A) produced by the placenta for this, which is also used for the calculation of the risk with regard to aneuploidies/syndromic disease, etc. as part of the risk calculation is required in first trimester screening. An additional determination of the PIGF does not increase the benefit as we now know. (https://doi.org/10.1002/uog.22093)
In addition to the blood test, the following factors influence the individual risk of developing individual symptoms or even the full picture (HELLP syndrome) of this disease.
- Maternal age
- blood pressure
- body length
- weight
- BMI
- ethnicity
- family and personal history and
- blood flow to the arteries supplying the uterus and placenta
Internationally one takes an individual risk of 1-5% (early preeclampsia/ PE) and worse to initiate a substitution with ASS 150mg once a day according to the ASPRE study. Intake should be continued up to 36+ weeks of pregnancy according to the study design.